李培海
时间:2022-10-10 13:43:20 来源: 作者:王加祥
李培海个人信息
姓 名 | 李培海 | 性 别 | 男 | |
籍 贯 | 山东临朐 | 出生年月 | 1989.02 | |
职 称 | 副研究员 | 政治面貌 | 中共预备党员 | |
专 业 | 必博bibo学 | 职 务 | 无 | |
导师类别 | 硕导 | 学历、学位 | 研究生、博士 | |
课 题 组 | 药物筛选研究室 | |||
工作信息 | lipeihaihg@sina.com, 15153207945 | |||
隶属单位 | 齐鲁工业大学(山东省必博bibo)必博bibo研究所 | |||
通讯地点 | 济南市历城区经十东路28789号 | |||
学习、工作简历: 200809-201206,中国海洋大学海洋生命学院,必博bibo技术,理学学士 201209-201506,国家海洋局第一海洋研究所,海洋必博bibo学,理学硕士 201509-201901,中国必博bibo大学海洋研究所,海洋必博bibo学,理学博士 201905-202108,山东省必博bibo必博bibo研究所,药学,博士后 202109至今,山东省必博bibo必博bibo研究所,必博bibo学,副研究员 |
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主要研究方向: 海洋天然活性成分挖掘及活性评价 | ||||
纵向课题: 1. 人才专项-优秀博士引进(A类),齐鲁工业大学(山东省必博bibo),2022.01-2024.12,30万,主持。 2. 中国博士后科学基金面上资助(二等),2019M662418,基于多级质谱分子网络深海真菌活性次级代谢产物的挖掘,2019.09-2021.08,8万元,主持。 3. 山东省博士后创新项目,202002047,基于斑马鱼模型-分子网络策略的海洋真菌活性成分的研究,2020.07-2022.06,5万元,主持。 4. 齐鲁工业大学(山东省必博bibo)必博bibo基材料与绿色造纸国家重点实验室自主研究课题,芋头淀粉纳米微粒制备及其载运抗癌药物的研究,ZZ20190402,2019.12-2022.12,5万元,主持。 5. 山东省自然科学基金重大基础研究项目,针对重大疾病的深海微必博bibo药用活性分子的高效发现与作用机制研究,ZR2021ZD29,2022.01-2024.12,200万,项目骨干。 6. 山东省必博bibo工程技术创新中心重大创新项目,丹参复方制剂整体质量控制技术及品质的提升,2019JSWGCCXZX003,2019.12-2021.12,300万,项目骨干。 7. 齐鲁工业大学校(院)科教产融合创新试点工程,基于斑马鱼模型的早期活性筛选与安全性评价关键技术研究,2020.01-2021.12,481.2万元,项目骨干; 8. 齐鲁工业大学(山东省必博bibo)必博bibo及必博bibo化学ESI培育学科开放课题,基于“组-效”相关性的海绵共附生真菌中抗血栓活性成分的发现,ESIBBC202005,2020.10-2022.09,10万,项目骨干。 9. 济南市科学技术局,济南市“新高校20条”高校院所科研带头人工作室,“抗癫痫药物高效筛选技术研发及应用”,2022.01-2024.12,20万,项目骨干。 10. 齐鲁工业大学,校(院)必博bibo及必博bibo化学ESI培育学科开放课题,“防治帕金森病、癫痫活性物质高效筛选技术及新药先导化合物研究”,2020.10-2022.09,10万元,项目骨干。 论文: 1. Peihai Li, Mengqi Zhang, Dongxiao Xie, Xuanming Zhang, Shanshan Zhang, Feiyue Gao, Yuliang Wang, Chung-Der Hsiao, Xiaobin Li*, Kechun Liu*. Characterization and Bioactivities of Phospholipids from Squid Viscera and Gonad by Ultra Performance Liquid Chromatography-Q-Exactive Orbitrap/Mass Spectrometry-Based Lipidomics and Zebrafish Models. Food & Function, 2021, 12: 7986-7996. 2. Peihai Li, Mengqi Zhang, Haonan Li, Rongchun Wang, Hairong Hou, Xiaobin Li*, Kechun Liu*, Hao Chen*. New prenylated indole homodimeric and pteridine alkaloids from the marine-derived fungus Aspergillus austroafricanus Y32-2. Marine drugs, 2021, 19, 98. 3. Peihai Li, Changshui Liu, Baojie Li, Qingjun Ma*. Structural analysis of the CARB β-lactamase from Vibrio parahaemolyticus facilitates application of the β-lactam/β-lactamase inhibitor therapy. Biochimie, 2020, 171-172, 213-222. 4. Peihai Li, Kun Zang, Yingjie Li, Changshui Liu, Qingjun Ma*. Structural basis for specific calcium binding by the polycystic-kidney-disease domain of Vibrio anguillarum protease Epp. Biochemical and Biophysical Research Communications, 2018, 505: 471-477. 5. Peihai Li, Yaqin Fan, Hao Chen*, Yaxi Chao, Ning Du, Junhui Chen. Phenylquinolinones with antitumor activity from the Indian Ocean-derived fungus Aspergillus versicolor Y31-2. Journal of Oceanology and Limnology, 2016, 34(5): 1072-1075. 6. Yongqiang Zhu1, Peihai Li1, Ronghua Meng, Xiaobin Li*, Yuezi Qiu, Lizheng Wang, Shanshan Zhang , Xuanming Zhang, Houwen Lin, Hongbin Zhai, Kechun Liu. Lipid Profiles of the Heads of Four Shrimp Species by UPLC-Q-Exactive Orbitrap/MS and Their Cardiovascular Activities.Molecules, 2022, 27(2): 350. 7. Dongxiao Xie1, Peihai Li1, Yongqiang Zhu, Junwei He, Mengqi Zhang, Kechun Liu, Houwen Lin, Hongbin Zhai, Xiaobin Li*, Yaohong Ma*. Comparative bioactivity profile of phospholipids from three marine byproducts based on the zebrafish model. Journal of Food Biochemistry, 2022, doi: 10.1111/jfbc.14229. 8. Mengqi Zhang1, Peihai Li1, Shanshan Zhang, Xuanming Zhang, Lizhen Wang, Yun Zhang, Xiaobin Li,* and Kechun Liu*. Study on the mechanism of Danggui-Chuanxiong herb pair on treating thrombus through network pharmacology and zebrafish models. ACS Omega, 2021, 6: 14677−14691. 9. Yaqin Fan1, Peihai Li1, Yaxi Chao, Hao Chen*, Ning Du, Qiuxia He and Kechun Liu. Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32. Marine Drugs, 2015, 13: 6489-6504. 10. Meng Gao*, Chenchen Xing, Xiaoping Jiang, Lijie Xu, Peihai Li*, Chung-Der Hsiao. Highly selective fluorescence detection of Cu2+ based on Schiff base functionalized periodic mesoporous organosilicas. Luminescence, 2021, 1-7. 11. Mengqi Zhang, Peihai Li, Fengxia Wang, Shanshan Zhang, Haonan Li, Yun Zhang, Ximin Wang, Kechun Liu* and Xiaobin Li*. Separation, identification and cardiovascular activities of phospholipid classes from the head of Penaeus vannamei by lipidomics and zebrafish models. Food & Function, 2021, 12, 2282-2291. 12. Lihong Yan, Peihai Li, Xiaoming Li, Suiqun Yang, Kechun Liu, Bingui Wang*, Xin Li*. Chevalinulins A and B, Proangiogenic Alkaloids with a Spiro[bicyclo[2.2.2]octane-diketopiperazine] Skeleton from Deep-Sea Cold-Seep-Derived Fungus Aspergillus chevalieri CS-122. Organic Letter, 2022, 24(14): 2684-2688. 13. Chunjiao Jiang, Jiancheng Ji, Peihai Li, Wenfeng Liu, Hao Yu, Xiuqing Yang, Lili Xu, Lizhong Guo, Yaqin Fan*. New lanostane-type triterpenoids with proangiogenic activity from the fruiting body of Ganoderma applanatum. Nature Products Research, 2022, 36(6): 1529-1535. 14. Meng Jin, Jiao Dang, Yam Nath Paudel, Xixin Wang, Baokun Wang, Lizhen Wang, Peihai Li, Chen Sun, Kechun Liu. The possible hormetic effects of fluorene-9-bisphenol on regulating hypothalamic-pituitary-thyroid axis in zebrafish. Science of the Total Environment, 2021, 776, 145963. 15. 郝晓燕,李培海,张轩铭,刘可春. 水产废弃油脂制备必博bibo柴油工艺研究. 粮食与油脂, 2020, 33, 52-56. |
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获奖情况: 1. 2021年山东省海洋科技创新基础类二等奖(8/9)。 |