纵向课题: (1)国家科学技术部,一带一路”创新人才交流外国专家项目,“抗神经系统疾病活性物质***”,2021.01-2022.12,30万,在研,主持; (2)济南市科学技术局,济南市“新高校20条”高校院所科研带头人工作室,“抗癫痫药物高效筛选技术研发及应用”,2022.01-2024.12,20万,在研,主持; (3)国家科学技术部,国家高端外国专家引进计划,“基于冠状病毒关键抗原***”,2020.01-2021.01,50万元,结题,主持; (4)国家自然科学基金委员会,国家自然科学基金青年基金,“EYA2通过与PAX6相互作用调控乳腺癌侵袭和转移的机制研究”,2019.01-2021.12,21万元,结题,主持; (5)齐鲁工业大学,校(院)科教产融合创新试点工程,“基于斑马鱼模型的早期活性筛选与安全性评价关键技术研究”,2020.01-2021.12,481.2万元,结题,子课题负责人; (6)山东省必博bibo青年基金,“由关键蛋白相互作用介导的乳腺癌侵袭和转移的调控机制研究”,2018.01-2019.12,10万元,结题,主持; (7)山东省必博bibo科技发展基金,“EYA2通过与PAX6相互作用调控乳腺癌侵袭和转移的机制研究”,2019.01-2021.12,10万元,结题,主持; (8)中国必博bibo沈阳分院—山东省必博bibo青年科学家合作伙伴项目,“没药烯工程菌株的优化及没药烯毒性活性评价”,2017.06-2019.06,3万元,结题,主持; (9)齐鲁工业大学,校(院)必博bibo及必博bibo化学ESI培育学科开放课题,“防治帕金森病、癫痫活性物质高效筛选技术及新药先导化合物研究”,2020.10-2022.09,10万元,在研,主持; (10)山东省必博bibo,人才专项“B类优秀博士引进”,2016.12-2019.12,15万元,结题,主持。 (11)山东省科学技术厅,山东省自然科学基金重大基础研究项目,“针对重大疾病的深海微必博bibo药用活性分子的高效发现与作用机制研究”,2022.01- 2024.12,200万,在研,参与; (12)山东省科学技术厅,山东省外专双百计划“抗神经系统疾病活性物质高效***”,2020.12-2023.12,300万,在研,核心成员; (13)济南市科学技术局, 济南市“新高校20条”高校院所引进高端人才项目,“神经保护天然活性成分的筛选及功能产品研发”,2022.01-2024.12,100万元,在研,核心成员; (14)山东省科学技术厅,山东省自然科学基金,“褪黑素受体在昼行动物斑马鱼视网膜中的表达及对自感光神经节细胞光反应的调制”,2018.03-2020.06,5万元,结题,参加; (15)齐鲁工业大学(山东省必博bibo)科教产融合创新试点工程,“军民两用新型碳基快速止血材料研发”,2020.01-2021.12,154万元,结题,核心成员; (16)山东省科学技术厅,山东省高端外国专家项目,“基于斑马鱼癫痫模型***”,2019.01-2019.12,20万元,结题,核心成员; (17)山东省科学技术厅,山东省重点研发计划(重大),“西洋参特色中药材产业链关键技术研究及健康产品研发”,2019.12-2021.12,350万元,结题,参与; (18)山东省必博bibo国际科技合作项目,“新型碳基止血材料的研发”,2019.01-2020.12,130万元,结题,核心成员; (19)山东省科学技术厅,山东省中青年科学家科研奖励基金,“海绵及其共附生微必博bibo来源的心血管药物先导化合物的发现”,2019.08-2024.12,100万元,在研,参与; (20)山东省科学技术厅,山东省重点研发计划,“以虾头废弃物为原料的多不饱和脂肪酸磷脂制备关键技术研究”,2019.01-2020.12,15万元,结题,参与; (21)山东省必博bibo,山东省必博bibo国际科技合作项目,“抗难治性癫痫的I类新药的研究与开发”,2019.01-2020.12,30万元,结题,参与; (22)山东省科学技术厅,山东省外专双百计划,“聚乙二醇化的必博bibo碱类***”,2019.12-2022.12,300万,在研,核心成员。 横向课题: (1)中药提取物抗帕金森状行为活性评价;(2)化合物ELB对斑马鱼新生血管的影响;(3)纳米二氧化硅通过自噬导致神经毒性的关键基因检测;(4)纳米二氧化硅诱发斑马鱼帕金森病的机制探究;(5)基于斑马鱼幼鱼模型的抗阿尔兹海默症活性物质筛选;(6)基于斑马鱼模型的神经保护化合物筛选;(7)多肽保护学习记忆能力的qPCR检测;(8)多肽的斑马鱼T迷宫检测;(9)酒花多酚抑制肿瘤增殖的CCK8检测;(10)海洋来源的必博bibo多糖定性定量检测及活性评价新技术;(11)基于斑马鱼模型的灭活乳酸菌及其代谢产物多活性必博bibo制剂开发;(12)紫荷冻干粉药效物质基础研究;(13)基于斑马鱼模型的化合物抗抑郁活性研究;(14)2个新结构样品对斑马鱼阿尔兹海默疾病模型的初步研究;(15)基于斑马鱼模型评价一种新材料的多种必博bibo活性;(16)化合物抗抑郁活性筛选和研究;(17)新型(裸藻粉)β-葡聚糖提高斑马鱼及细胞免疫活性的研究;(18)基于斑马鱼模型的天然发酵因子功效评价及作用机制研究;(19)雪沐年华灵芝维稳和雪沐年华虫草系列护肤品的舒缓与紧致功效评价;(20)基于斑马鱼模型评价酸枣仁提取物的助眠活性;(21)基于斑马鱼模型的扎冲十三味丸促进卒中后血管生成活性评价;(22)基于斑马鱼模型评价化合物对酒精性肝损伤的保肝活性;(23)基于斑马鱼模型评价桑黄子实体降血糖活性评价;(24)四种样品的急性发育毒性与皮肤刺激性分析以及啤特果的多种护肤功效与刺激性检测;(25)不同透明质酸盐的抗氧化活性评价;(26)基于斑马鱼模型的样品刺激性检测。 论文(近五年,以第一作者或通讯作者发表的SCI论文): 1. Song Y, Liu S, Jiang X, Ren Q, Deng H, Paudel YN, Wang B, Liu K, Jin M*: Benzoresorcinol induces developmental neurotoxicity and injures exploratory, learning and memorizing abilities in zebrafish. The Science of the total environment 2022, 834:155268. 2. Ren Q#, Jiang X#, Zhang S#, Gao X, Paudel YN, Zhang P, Wang R, Liu K, Jin M*: Neuroprotective effect of YIAEDAER peptide against Parkinson's disease like pathology in zebrafish. Biomedecine & pharmacotherapie 2022, 147:112629. 3. Ren Q#, Jiang X#, Paudel YN, Gao X, Gao D, Zhang P, Sheng W, Shang X, Liu K, Zhang X*, Jin M*: Co-treatment with natural HMGB1 inhibitor Glycyrrhizin exerts neuroprotection and reverses Parkinson's disease like pathology in Zebrafish. Journal of ethnopharmacology 2022, 292:115234. 4. Li X#, Gao D#, Paudel YN, Li X, Zheng M, Liu G, Ma Y, Chu L, He F*, Jin M*: Anti-Parkinson's Disease Activity of Sanghuangprous vaninii Extracts in the MPTP-Induced Zebrafish Model. ACS chemical neuroscience 2022, 13(3):330-339. 5. Wang R#, Ren Q#, Gao D#, Paudel YN, Li X, Wang L, Zhang P, Wang B, Shang X*, Jin M*: Ameliorative effect of Gastrodia elata Blume extracts on depression in zebrafish and cellular models through modulating reticulon 4 receptors and apoptosis. Journal of ethnopharmacology 2022, 289:115018. 6. Jin M#, Li N#, Sheng W, Ji X, Liang X*, Kong B, Yin P, Li Y, Zhang X, Liu K*: Toxicity of different zinc oxide nanomaterials and dose-dependent onset and development of Parkinson's disease-like symptoms induced by zinc oxide nanorods. Environment international 2021, 146:106179. 7. Ren Q#, Gao D#, Mou L#, Zhang S, Zhang M, Li N, Sik A, Jin M*, Liu K*: Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish. European journal of pharmacology 2021, 912:174589. 8. Dang J#, Paudel YN#, Yang X#, Ren Q, Zhang S, Ji X, Liu K, Jin M*: Schaftoside Suppresses Pentylenetetrazol-Induced Seizures in Zebrafish via Suppressing Apoptosis, Modulating Inflammation, and Oxidative Stress. ACS chemical neuroscience 2021, 12(13):2542-2552. 9. Ji X#, Wang B#, Paudel YN#, Li Z, Zhang S, Mou L, Liu K, Jin M*: Protective Effect of Chlorogenic Acid and Its Analogues on Lead-Induced Developmental Neurotoxicity Through Modulating Oxidative Stress and Autophagy. Frontiers in molecular biosciences 2021, 8:655549. 10. Jin M, Dang J, Paudel YN, Wang X, Wang B, Wang L, Li P, Sun C, Liu K*: The possible hormetic effects of fluorene-9-bisphenol on regulating hypothalamic-pituitary-thyroid axis in zebrafish. The Science of the total environment 2021, 776:145963. 11. Li X, Dang J, Li Y, Wang L, Li N, Liu K, Jin M*: Developmental neurotoxicity fingerprint of silica nanoparticles at environmentally relevant level on larval zebrafish using a neurobehavioral-phenomics-based biological warning method. The Science of the total environment 2021, 752:141878. 12. Wang L#, Sheng W#, Tan Z, Ren Q, Wang R, Stoika R, Liu X, Liu K, Shang X*, Jin M*: Treatment of Parkinson's disease in Zebrafish model with a berberine derivative capable of crossing blood brain barrier, targeting mitochondria, and convenient for bioimaging experiments. Comparative biochemistry and physiology Toxicology & pharmacology : CBP 2021, 249:109151. 13. Jin M, Ji X, Stoika R, Liu K, Wang L*, Song Y: Synthesis of a novel fluorescent berberine derivative convenient for its subcellular localization study. Bioorganic chemistry 2020, 101:104021. 14. Jin M, Gao D, Wang R, Sik A, Liu K*: Possible involvement of TGFbeta-SMAD-mediated epithelialmesenchymal transition in prometastatic property of PAX6. Oncology reports 2020, 44(2):555-564. 15. Jin M#,*, Zhang B#, Sun Y#, Zhang S, Li X, Sik A, Bai Y*, Zheng X*, Liu K*: Involvement of peroxisome proliferator-activated receptor gamma in anticonvulsant activity of alpha-asaronol against pentylenetetrazole-induced seizures in zebrafish. Neuropharmacology 2020, 162:107760. 16. Zhang S, Yu Z, Xia J, Zhang X, Liu K, Sik A, Jin M*: Anti-Parkinson's disease activity of phenolic acids from Eucommia ulmoides Oliver leaf extracts and their autophagy activation mechanism. Food & function 2020, 11(2):1425-1440. 17. Zhang B#, Wang L#, Ji X#, Zhang S, Sik A, Liu K, Jin M*: Anti-Inflammation Associated Protective Mechanism of Berberine and its Derivatives on Attenuating Pentylenetetrazole-Induced Seizures in Zebrafish. Journal of neuroimmune pharmacology 2020, 15(2):309-325. 18. Shang X#, Ji X#, Dang J, Wang L, Sun C, Liu K, Sik A, Jin M*: alpha-asarone induces cardiac defects and QT prolongation through mitochondrial apoptosis pathway in zebrafish. Toxicology letters 2020, 324:1-11. 19. Shang X*, You C, Li X, Yuan L, Jin M*, Zhang X*: Involvement of 5-HT2 serotonin receptors in cognitive defects induced by aristolochic acid I in mice. Toxicology 2020, 447:152624. 20. Li X, Ji X, Wang R, Zhao J, Dang J, Gao Y, Jin M*: Zebrafish behavioral phenomics employed for characterizing behavioral neurotoxicity caused by silica nanoparticles. Chemosphere 2020, 240:124937. 21. Jin M, Xiao Z, Zhang S, Men X, Li X, Zhang B, Zhou T, Hsiao CD, Liu K*: Possible involvement of Fas/FasL-dependent apoptotic pathway in alpha-bisabolol induced cardiotoxicity in zebrafish embryos. Chemosphere 2019, 219:557-566. 22. Jin M#, Ji X#, Zhang B, Sheng W, Wang R, Liu K*: Synergistic effects of Pb and repeated heat pulse on developmental neurotoxicity in zebrafish. Ecotoxicology and environmental safety 2019, 172:460-470. 23. Li X, Kong H, Ji X, Gao Y, Jin M*: Zebrafish behavioral phenomics applied for phenotyping aquatic neurotoxicity induced by lead contaminants of environmentally relevant level. Chemosphere 2019, 224:445-454. 24. Li X, Zhang B, Li N, Ji X, Liu K*, Jin M*: Zebrafish neurobehavioral phenomics applied as the behavioral warning methods for fingerprinting endocrine disrupting effect by lead exposure at environmentally relevant level. Chemosphere 2019, 231:315-325. 25. Jin M, Sheng W, Han L, He Q, Ji X, Liu K*: Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish. Fish & shellfish immunology 2018, 83:26-36. 26. Jin M, He Q, Zhang S, Cui Y, Han L*, Liu K*: Gastrodin Suppresses Pentylenetetrazole-Induced Seizures Progression by Modulating Oxidative Stress in Zebrafish. Neurochemical research 2018, 43(4):904-917. 专利: (1)一种蛇毒凝血酶原激活物及基于蛇毒凝血酶原活无的快速止血材料,ZL202010409822.0,2021.05.14; (2)一种凝血酶原激活因子及含凝血酶原激活因子的快速止血材料,ZL202010434949.8,2021.05.11; (3)一种基于聚合氨基酸的多组分创面修复止血敷料及其应用,ZL202111313043.1,2022.06.21; (4)一种交联壳聚糖微球及其在创面止血修复材料中的应用,ZL202111316731.3,2022.06.21; (5)一种用于药物筛选的阿尔兹海默症模型的构建方法,ZL201811135578.2,2020.10.30; (6)一种基于双香豆素衍必博bibo的过氧化亚硝酸盐荧光探针、制备方法与应用,ZL201911289368.3,2020.12.01; (7)一种鼠李糖或核糖修饰的小檗碱盐衍必博bibo及其制备方法和用途,ZL201810722418.1,2019.07.23; (8) 一种评价鱼体耐力的装置,ZL 2018213195410,2019.03.18; (9)一种从南极磷虾中提取高纯度海洋磷脂的方法,ZL201611146703.0,2018.06.29。 |